Inbreeding has become a hot topic in recent years…

Producer concern is on the rise over whether genomics is creating too much inbreeding in the dairy cattle population. The worry is that there will soon be limited options to which a herd can be bred to avoid negative effects of inbreeding. Mating an animal to her father or brother is certainly not desirable, but we need to ask what the real goal is in terms of inbreeding. Should we aim for zero percent inbreeding or rather manage it to maximize profit?

The linear effect of inbreeding depression

As animals become more related to each other, inbreeding depression or sub-par productive performance can occur. Inbreeding depression is not ideal, but it should still be weighed against the potential added value from genetic gain.

A common misconception is there is a magic level of inbreeding that we should never go beyond for any given mating. In reality, numerous studies over time have shown the effects of inbreeding depression to be linear.

For every 1% increase in inbreeding for a mating, you will realize $22-24 less profit over the life of the resulting offspring. The same cost, or loss, is predicted when going from 9% to 10% inbreeding as is expected between 1% and 2%.

Genetic progress

It’s well-documented that inbreeding has been on the rise since the mainstream adoption of AI. Despite this increase, dairy cattle have made significant strides in production traits like milk, fat, and protein. It’s safe to say that producers would not trade today’s high producing cows for the less inbred, but also lower producing, cows of the 1960’s.

Inbreeding and milk production graph

Real-world examples

Let’s look into the records of a random cross-section of 10 upper Midwest dairies averaging 1,500 cows, who implement a mating program on their farm. This analysis shows how cows with superior genetics are more productive than cows with inferior genetics, despite the more highly productive group also being more inbred.

In this analysis, cows born between 2005 and 2010, with at least one lactation on record were included. Each individual herd was first analyzed separately, and cows were split into quartiles based on their individual level of inbreeding.

Total # of cows% InbredNM$Milk Deviation1st Lact 305-Day MilkPTA DPRAvg. 1st Lact Preg RatePTA PL
25% MOST inbred from each herd38107.0158649282580.422.51.4
25% LEAST inbred from each herd37844.5121296278750.422.60.9

Here, you can see the difference in genetics, 1st lactation milk production, and NM$ between the top 25% most inbred from each herd and top 25% least inbred animals from each herd. The most highly inbred quartile of cows was also the most genetically superior group of cows in each of these ten herds.

Despite the elevated inbreeding in the most highly inbred quartile of each herd, the genetics more than make up for that when their actual performance is measured. The NM$ levels, pounds of milk and milk deviations were all favorable for the more highly inbred, but also more genetically superior group.

This is not to say that selecting a mating resulting in a 25% inbreeding level is the best option, but rather that when managed properly as part of a program, excellent genetics can more than make up for predicted inbreeding depression.

What many producers also don’t realize is that current proof values of a bull already account for the level of predicted future inbreeding. Adjustments are made in favor of a bull that is considered an outcross sire, and a bull that is more closely related to the average population will see a negative impact on his PTAs because of these adjustments.

Manage inbreeding to maximize profit

To manage inbreeding, we look to an example to see how managing, rather than avoiding inbreeding is the best route.

The example below shows three options to use for a mating in your herd. Sire 1 and sire 2 both offer high Net Merit $ levels. However, their 8% and 6.5% inbreeding levels would be above the suggested 6.25% industry standard, which would eliminate them as potential mating sires in many breeding programs. Sire 3 would be a logical outcross mating in this example, resulting in a mere 1% inbreeding.

Sire OptionSire NM$Inbreeding % with cow being bredEconomic loss due to inbreedingAdjusted NM$ for level of inbreeding
18548.0184693
28456.5150695
36051.023582

Above-average inbreeding levels would result from this female’s mating with sire 1 or sire 2. Yet both of these choices would still produce a much more profitable mating over the life of the resulting offspring than a mating to sire 3, even after the adjustment for inbreeding depression is accounted for.

So while 6.25% is often considered the industry norm inbreeding limit, there are often cases when a mating beyond that level of inbreeding still produces the best potential for future profit.

Within your herd, a two-part approach to record management and mating can help maximize your future profit potential.

  • Maintain accurate animal identification

Inbreeding cannot be managed if it cannot be measured. It’s impossible to know what the predicted inbreeding level will be if you do not keep accurate records on your animals. A mating you thought would be a minimal 1% or 2% could easily become 12% or more if an animal is misidentified, or if correct records are not kept.

  • Make the right mating program work for you

With accurate identification in place, a mating program can offer a solution to manage inbreeding. And while a mating program can manage inbreeding, the first step is actually to select which bulls best fit your genetic plan (see Sire selection vs mating article by Zwald). If you select the best bulls available to meet your goals, and keep only those bulls in your tank, then you automatically avoid poor mating decisions – provided that you manage inbreeding to appropriate levels.

After you’ve selected the best bulls for your genetic plan, the more traditional mating method suggests a 1st, 2nd, and 3rd choice sire from that group of bulls. Each of the three choices would ensure a mating below your set maximum inbreeding level.

A simpler mating method is a “pen mate.” This takes the opposite approach of a traditional mating program. Instead of trying to find the perfect mating for a cow or heifer, a pen mate lists the bulls in your tank that should not be used on any given female to avoid a mating that exceeds your set inbreeding maximum.

A pen mate also increases efficiency and accuracy for technicians on big breeding days. A technician can forego the stress of loading five AI guns with five different bulls, making sure each cow is bred to the correct bull, and that each insemination is then recorded accurately. Instead, the technician can head to the pen to breed with five AI guns all loaded with one bull that appropriately manages inbreeding for all five cows. The pen mate aids in accurate record-keeping, and provides peace of mind that inbreeding is properly managed.

Takeaways on inbreeding

With all of this in mind, it’s important to ask yourself if your goal is to eliminate inbreeding in your herd, or to maximize profit potential.

  1. The average inbreeding of animals is on the rise, but so are genetic values and average production levels.
  2. Instead of aiming for zero percent, or even sticking to the industry standard 6.25% inbreeding maximum, the goal should be to manage inbreeding levels. This way you can capitalize on genetic progress and maximize potential future profits.
  3. Accurate identification and records are key to managing inbreeding in your herd.
  4. A simple pen mate program can give you added peace of mind that inbreeding levels are kept below your desired maximum.
  5. Proper sire selection to fit your genetic plan will ensure no mating is a bad one.

 

Sources

  1.  Smith LA, Cassell BG, Pearson RE. Effects of Inbreeding on Lifetime Performance of Dairy Cows. Advances in Dairy Technology. Volume 11. (1999) 13.
  2. CDCB. Trend in Milk BV for Holstein or Red & White, calculated August 2014. Web. 1 Oct 2014.